The spiritual significance of a two-dollar bill varies across different cultures and traditions. Some see it as a symbol of balance, harmony, and good luck, while others view it as a rare and unique object with enhanced spiritual power. The eagle on the back is seen as representing freedom and strength in Native American culture, while Hindus may offer it as an offering to their deities for good fortune. The tradition of giving two-dollar bills as gifts is thought to have originated during the Great Depression.